In the rapidly growing market for charging infrastructure systems for electromobility, we are a sought after partner for highly efficient, customized charging solutions. No matter what. Register for a free introduction to the Han Configurator or start directly with your first configuration. The IIoT is made up of interconnected machines and devices that can monitor, collect, exchange, and analyze data. Founded in 1942, it has a workforce of over 7,600 based in various production, service and engineering locations across Switzerland, Germany, Spain, Poland, Hungary, the Czech Republic, Belarus and the United States.https://www.stadlerrail.com, The European XFEL is a research facility of superlatives: It generates ultrashort X-ray flashes - 27 000 times per second and with a brilliance that is a billion times higher than that of the best conventional X-ray radiation sources. The study followed standard procedures in France, with approval by the relevant institutional review boards. Quick and easy handling industrial connectors, robust, flexible in use, a long life cycle and, ideally, a tool-free assembly - whatever you expect from a connector Hanwont disappoint you. Dihydropyrimidine dehydrogenase and uridine diphosphate glucurono-syltransferase (UGT) 1A1 are two key enzymes involved in the catabolic pathways of 5-FU and irinotecan, respectively. US . All of these are reasons that companies are turning to Industry 4.0. FOLFOXIRI is feasible in L1 in patients with aPDAC but does not confer any therapeutic benefit as compared with FOLFIRINOX. we can transform a standardized connector housing into a customized solution for your company. The HARTING's modular and compacthar-link interface connector systemin 2.0mm pitch allows fast and reliabledata transfer rates up to 2 Gbit/s. The primary analysis was conducted using data from the total population, and compared characteristics and outcomes between the FOLFIRINOX and FOLFOXIRI groups. Ducreux M, Cuhna AS, Caramella C, Hollebecque A, Burtin P, Gor D, Seufferlein T, Haustermans K, Van Laethem JL, Conroy T, Arnold D ESMO Guidelines Committee. Trains travel at high speeds through harsh environments. Moreover, no difference in objective response (P = 0.317), maintenance chemotherapy (P = 1.000), or second-line administration rates (P = 1.000) was observed. This consent allows the use of their clinical and biological data in the cohort study. A guide to modularity in production technology, System concepts for the most important trends in the railway industry, Future outlook for DC connectivity in the industrial environment, Customised industrial connectors with the Han Configurator, Safe connections for modular battery storage systems, Simplifying electrical cabinet construction, free introduction to the Han Configurator, Many hood and housing options, sizes, designs, cable outlets, etc. As there are many different types of objects that can be tracked, and specific requirements for each object, several technologies exist to accomplish all the different asset tracking solutions. FOLFIRINOX or Gemcitabine as Adjuvant Therapy for Pancreatic Cancer. It is available in file formats PDF, CMG and DXF. Hanindustrial connectors provide for a reliable and pluggable transmission of power, signal and data, meeting the highest requirements. No treatment-related deaths were observed. Such connectors can handle the data and signal transmissions required for monitoring the facilities. Manuscript source: Unsolicited Manuscript, P-Reviewer: Sun XT, Rungsakulkij N S-Editor: Wang YQ L-Editor: Webster JR E-Editor: Liu JH. Properties Overview. Elisabeta Gherga, Department of Medical Oncology, Nord Franche-Comt Hospital, Montbliard F-25020, France. They reported that FOLFOXIRI improved patient survival rates with a median OS of 12 mo for the overall population and 10.8 mo for the metastatic patients. The portfolio ranges from simple assembly and disassembly tools, manual and semi-automatic hand tools to fully automated machines - for an efficient processing of contacts and connectors. Schemper M, Smith TL. By combining machine-to-machine communications with analytics, companies can reap the benefits of unparalleled efficiency, productivity, and performance. Medians and proportions were compared between the FOLFIRINOX and FOLFOXIRI groups using WilcoxonMannWhitney and chi-square tests (or Fishers exact test, if appropriate), respectively. The portfolio ranges from simple assembly and disassembly tools, manual and semi-automatic hand tools to fully automated machines - for an efficient processing of contacts and connectors. In addition, two meta-analyses suggested that dosage attenuation improves tolerance while preserving survival benefits (overall response rates: 32% with modified FOLFIRINOX vs 33% with full doses; P = 0.879)[24,25]. Building a predictive maintenance system. In order to increase the flexibility of modular manufacturing a connector must offer rapid installation, effortless exchange, and simple troubleshooting. Phase III trial of infusional fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) compared with infusional fluorouracil, leucovorin, and irinotecan (FOLFIRI) as first-line treatment for metastatic colorectal cancer: the Gruppo Oncologico Nord Ovest. In previous retrospective and single-arm phase II studies, the bolus of 5-FU was more frequently discontinued in the modified FOLFIRINOX combination[10,28-31]. Detailed outcomes data are summarized in Table Table2.2. Hematopoietic growth factors were used after each chemotherapy cycle and the low hematological toxicity rates were below 5% with both regimens. unburdens highly complex technical components such as switch cabinets and requires practically no tools for assembly. Usn Junior PLS, Rother ET, Maluf FC, Bugano DDG. How do you like our redesigned product page? What is Han-Eco? INSERM CIC-1431, Clinical Investigation Center in Biotherapy, Besanon University Hospital, Besanon F-25030, France. . In the adjuvant setting, a modified FOLFIRINOX with no bolus of 5-FU and irinotecan at a dose of 150 mg/m2 significantly increased survival compared to gemcitabine for PDAC[4]. Of note, this incidence was similar to the gastrointestinal safety profile reported by Vivaldi et al[21] with FOLFOXIRI chemotherapy. Early Breast Cancer Trialists' Collaborative Group (EBCTCG) Increasing the dose intensity of chemotherapy by more frequent administration or sequential scheduling: a patient-level meta-analysis of 37298 women with early breast cancer in 26 randomised trials. Industrial connectors transmit power and signals between electrical cabinets and robots. STROBE statement: The authors have read the STROBE Statement checklist of items, and the manuscript was prepared and revised according to the STROBE Statement checklist of items. These dose adjustments were also effective in the neoadjuvant setting for patients with locally advanced or borderline PDAC. In addition, a perfect crimp connection is gas-tight and therefore corrosion-resistant. Second-line chemotherapy was administered to 91 (73.4%) patients in the FOLFIRINOX group and 117 (70.9%) patients in the FOLFOXIRI group (P = 0.643). These results are in line with those observed in our study. For our most frequently installed solutions, we have also created video instructions. To investigate the potential clinical value of FOLFOXIRI in patients with advanced PDAC (aPDAC) in routine clinical practice. Image is for illustration purposes only. Han-Eco includes a range of hoods and housings made of high-performance plastic. The Industrial Internet of Things (IIoT) connects machines, analytics, and people to create powerful insights to drive smarter, faster, and better business decisions. Preemptive screening of DPYD and UGT1A1 variants could identify patients at risk of clinically relevant adverse events, to improve FOLFIRINOX administration[43]. Advanced or recurrent PDAC remains a challenging, non-curable disease, for which therapeutic options are still limited and mainly rely on supportive care and systemic chemotherapy to improve patient OS and health-related quality of life (HRQoL)[5]. When the decision is made to integrate IIoT, there are two possible strategies. . In addition, it has been shown that most patients who undergo surgery develop further tumor recurrence[4]. They can be used for a quick and easy use of HARTING products in CAx engineering processes. The Han-Modular series allows the combination of multiple media types - power, signal, data, air, and more into a single rectangular connector. Heavy Duty Connector Assemblies HARTING 10200100000 Share Image shown is a representation only. Kaplan-Meier curves of overall survival and progression-free survival for the FOLFIRINOX and FOLFOXIRI groups in the overall population and the propensity scorematched population. Han-Modular Connectors can combine electrical, optical, and gaseous signal and power connections in one easy assembly. Amstutz U, Froehlich TK, Largiadr CR. Grade 3 or 4 toxicities occurred in 19.5% of patients in the FOLFIRINOX group as compared with 28.7% in the FOLFOXIRI group, but this difference did not reach statistical significance (P = 0.079). Thus, primary tumor site, stage at diagnosis, stage at chemotherapy initiation, number of metastatic sites, lymph node and liver metastases, and pain were included in the propensity score (Supplementary Table 2). A primary prophylactic administration of hematopoietic growth factors contributed to the reduction of grade 3 or 4 neutropenia[22,23], and thus, routine use after each polychemotherapy cycle has been adopted in some institutions. The HRQoL of patients was significantly better with FOLFIRINOX as compared with gemcitabine, except for diarrhea[9]. . In conclusion, FOLFOXIRI is feasible in L1 in patients with aPDAC, but does not appear to confer any therapeutic benefit as compared with the FOLFIRINOX regimen. For HARTING, the D-Sub is more than just a bus connector. You can go directly to the shop here, and get detailed information about all HARTING products. Institutional review board statement: This project was approved by the National French Commission for bioinformatics data and patient liberty (CNIL; No. The main objective of ATEPS is to develop and market new technologies that accelerate the transition to a sustainable energy system.http://ateps.com, Hoods and housings in the eShop: Han A This regimen consisted of a combination of oxaliplatin (85 mg/m2, over 2 h), followed by leucovorin (400 mg/m2, over 2 h), with the addition through a Y-connector, after 30 min, of irinotecan (180 mg/m2, over 90 min), followed by 5-FU (400 mg/m2) by intravenous bolus, on Day 1. Median OS was significantly longer in the FOLFIRINOX group (13.3 mo; 95%CI: 10.7-15.5) compared to the FOLFOXIRI group (8.5 mo; 95%CI: 6.7-10.2) (HR= 1.44; 95%CI 1.07-1.94; P = 0.017; Supplementary Figure 3A). This series meets all the electrical requirements for implementing of high-quality connectivity solutions in hazardous locations in the Americas. To overcome these limitations, FOLFOXIRI and FOLFIRINOX were compared from a large population-based cohort of prospectively included patients with aPDAC. In the energy sector, reliable connections are critical for generation and transmission: connectors are used e.g. A guide to modularity in production technologySystem concepts for the most important trends in the railway industryFuture outlook for DC connectivity in the industrial environmentCustomised industrial connectors with the Han ConfiguratorSafe connections for modular battery storage systemsSimplifying electrical cabinet construction After propensity score matching, survival rates remained similar between the regimens in terms of overall survival and progression-free survival. Vienot A, Chevalier H, Turpin A, Borg C, Vernerey D contributed to data interpretation. However, implementing a solution specific to an existing factory can seem overwhelming. The use of plastic also brings significant weight and cost advantages over metal hoods and housings. From scanning groceries at a check out, to monitoring shipping containers as they cross oceans, below is a brief overview of the different technologies involved to make these types of applications happen. Bethesda, MD 20894, Web Policies HARTING PushPull connectors are the fastest and simplest solution for device connection technology in industrial and automation environments. The insert offers now a tool-less rapid termination technology. Furthermore, propensity score analysis was performed in metastatic patients (Supplementary Tables 5 and 6, Supplementary Figures 4 and 5). Please refer to product description. Li X, Ma T, Zhang Q, Chen YG, Guo CX, Shen YN, Sun PW, Li GG, Gao SL, Que RS, Lou JY, Yu RS, Yuan Y, Wei QC, Wei SM, Zhang Y, Zheng L, Bai XL, Liang TB. HARTING offers a comprehensive portfolio of cable termination tools for all relevant termination techniques and assembly steps. 68 talking about this. Armed with an innovative spirit and a zest for action, we threw outdated thinking overboard and pursued new approaches. Breakthrough Single Pair Ethernet Technology, har-port Service Interfaces for Ethernet and USB, Ha-VIS preLink - for Ethernet Connectivity, Machinery - Food processing and packaging, Governor Rauner & HARTING Announce Expansion, Solutions for Critical Medical Applications, HARTING Industrial Connectors - Configurator And Savings Calculator, Customer information - Terms and Conditions, 75th anniversary of the HARTING Technology Group. No matter what. Received 2019 Aug 24; Revised 2019 Dec 26; Accepted 2020 Jan 14. Furthermore, more than 80% of cases are diagnosed at an advanced, unresectable stage, with almost 50% of patients presenting with metastatic disease and almost 30% with locoregional extension[1]. Pancreatic ductal adenocarcinoma (PDAC) carries a poor prognosis, with a 5-year overall survival (OS) rate of only 8%-9% for all stages taken together[1]. Sensor Cables / Actuator Cables. The Han rectangularconnectorhousing with its sealing and locking mechanism protect the connection from external influences such as mechanical shocks, foreign bodies, humidity, dust, water or other fluids such as cleansing and cooling agents, oils, etc. The choice of the right termination technique depends mainly on the type of cable, the cable cross-section, as well as the number and type of contacts. P < 0.05 were considered statistically significant, and all tests were two-sided. Networks in modern production facilities are becoming increasingly complex. The database was locked on April 23, 2019. Similarly, patients treated with the FOLFIRINOX regimen had more favorable PFS (6.7 mo; 95%CI: 5.7-7.8; vs 3.9 mo; 95%CI: 2.9-6.1, respectively), but the difference was not statistically significant (HR= 1.30; 95%CI: 0.97-1.72; P = 0.073; Supplementary Figure 3B). Plug-in cable assemblies simplify installation and reduce maintenance costs. Sensor Cables / Actuator Cables TYPE MS4800-CBLRX-50M SAFETY LIGHT CURTAIN CABLE. Save money and time during the installation due to plug and play. FOLFIRINOX chemotherapy remains the standard of care in L1 in metastatic PDAC. The HARTING catalogue offers a wide range of Interface connectors, Circular connectors, 7/8 and many more products for electronic devices. 27440204 Contact for industrial connectors. Moreover, the schedule showed a good tolerance profile with the occurrence of grade 3 diarrhea in only 8%, and febrile neutropenia (grade 3 or 4 neutropenia 35.7%) in < 1%. From individual components in process technology through to fully assembled and installed analysis containers for online analysis.https://www.cgs-prozessanalytik.de, ATEPS Nederland BV is a new and growing company in the field of energy storage and energy efficiency. Related Content HARTING Han Industrial Connector Configurator Han-Modular History Objective tumor response was determined according to Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 criteria[13]. The har-modular from HARTING, https://www.tme.eu/en/katalog/?search. The reproducibility obtained with the sensitivity analysis in the metastatic cohort strengthened the observed results. The HARTING Technology Group offers a broad modular ethernet system for the implementation of innovative and future-proof Ethernet cabling. 7/8 Cable Assembly 2p+PE st/- f/- 0,5m Article. Tempi di installazione ridotti di oltre il 25%. Integrating IIoT functionalities has become essential for train companies and transit authorities who want to improve the safety, reliability, and maintenance of their systems. Certificates - Corporate Social Responsibility. We offer you a comprehensive range of services in the field of process analysis. Infusion of 5-FU is preferred for the treatment of colorectal cancer over bolus 5-FU. This is made possible by combining individual modules for different transmission media. Notices:1.) The easy and tool-free RJ45 field assembly plug. FOLFOXIRI might contribute to a better balance in the toxicity/efficacy ratio in this setting. Connecting and powering the world. All statistical tests were two-sided. Median OS and PFS were comparable between the two schedules, and similar to survival rates reported by Conroy et al[7] in FOLFIRINOX-treated patients. Propensity score construction was based on probability estimation with a nonparsimonious multivariable logistic regression model including the main parameters distributed unequally between the FOLFIRINOX and FOLFOXIRI groups. Prior to shipment, all products undergo comprehensive mechanical testing and electronic performance verification according to widely recognized industry standards and customer specifications. is based on the traditional DIN 41612 and is a customer configurable connector, for industrial board-to-board application.. TOPICS AND SESSIONS: MARCH 24, 2022 Guide to Modular Industrial Connectors + Engineering Data & Services APRIL 28, 2022 New Han-Modular Solutions for High-Speed Data Transmission MAY 18, 2022. rf.mresni@toneiv.euqilegna. Wang ZQ, Zhang F, Deng T, Zhang L, Feng F, Wang FH, Wang W, Wang DS, Luo HY, Xu RH, Ba Y, Li YH.
Immunity Formula With Elderberry And Echinacea, Kendra Scott Merrick Chain Necklace, Best Coaching For Nid Entrance, Bulk Cream Cheese Frosting Recipe, Igloo Overland 25 Vs Lifetime 28, Extra Wide Dog Ramp For Stairs, Best Blinds For Shower Window, Olympia Recon 2 Motorcycle Pants, Supreme Yankees Jacket Gore-tex,
cross bracelet mens leather